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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/21505


Title: V3 Peptide Binding Pattern and HIV-1 Transmission Route in Rio de Janeiro
Authors: Pinto, Monica E
Schechter, Mauro
Keywords: HIV - AIDS - V3 loop - antigenic variation - Brazil
Issue Date: 31-Dec-1995
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 90 Num 6
Abstract: To characterize antibody binding to a panel of V3 loop peptides representing diverse HIV-1 neutralization epitopes, 149 HIV-1 infected individuals from Rio de Janeiro (RJ) were investigated. Results were analyzed with respect to risk factors for infection and other epidemiological and clinical data. Peptide reactivity was not associated with sex, clinical status, CD4 counts, antigenemia or b2-microglobulin serum level. A segregation of peptide reactivity according to route of infection was encountered. This finding suggests that more then one viral strain may be circulating in RJ, in subjects with different risk factors for HIV-1 infection. An investigation of prevalent HIV-1 genotypes, serotypes and immunotypes may be of importance for the design and selection of potential vaccines to be used in Brazil as well as for the selection of populations to be included in future vaccine efficacy trials.
URI: http://hdl.handle.net/1807/21505
Other Identifiers: http://www.bioline.org.br/abstract?id=oc95138
Rights: Copyright 1995 Fundacao Oswaldo Cruz FIOCRUZ
Appears in Collections:Bioline International Legacy Collection

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