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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/21988


Title: Utility of polymerase chain reaction as a diagnostic tool in cutaneous tuberculosis
Authors: Padmavathy, L.
Rao, Lakshmana L.
Veliath, A. J.
Keywords: Cutaneous tuberculosis, PCR, Rapid diagnosis
Issue Date: 31-Dec-2003
Publisher: Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)
Citation: Indian Journal of Dermatology, Venereology and Leprology (ISSN: 0378-6323) Vol 69 Num 3
Abstract: Background: Differentiation of cutaneous tuberculosis from other infective granulomas of the skin is difficult due to paucity of the organisms in tissue biopsies. Polymerase chain reaction (PCR) is a newer technique to identify the DNA of Mycobacterium tuberculosis   in the tissues. Aim: We examined the utility of PCR as a tool for rapid diagnosis of cutaneous tuberculosis especially in cases negative by ZN staining and culture. Material and Methods: Twenty five random skin biopsies from patients with various types of cutaneous tuberculosis were subjected to PCR. Results: An overall positivity of 64% was observed, which is comparable to other series. Seventy five percent of lupus vulgaris cases, 62.2% of tuberculosis verrucosa cutis and 50% of scrofuloderma cases showed PCR positivity. Conclusion: Though useful, the cost and the technique involved limit the use of PCR in developing countries like ours.
URI: http://hdl.handle.net/1807/21988
Other Identifiers: http://www.bioline.org.br/abstract?id=dv03006
Rights: Copyright 2003 Indian Journal of Dermatology, Venereology & Leprology. Free full text also at http://www.ijdvl.com
Appears in Collections:Bioline International Legacy Collection

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