|Title: ||Parasite Genotypically Related to a Monoxenous Trypanosomatid of Dog's Flea Causing Opportunistic Infection in an HIV Positive Patient|
|Authors: ||Pacheco, Raquel S.|
Marzochi, Mauro C. A.
Pires, Marize Quinhones
Brito, Celia Maria Marques
Madeira, Maria de Fatima
Barbosa-Santos, Elizabeth Gloria Oliveira
|Keywords: ||opportunistic infection - AIDS - monoxenous trypanosomatid - minicircle
|Issue Date: ||31-Dec-1998|
|Publisher: ||Fundação Oswaldo Cruz, Fiocruz|
|Citation: ||Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 93 Num 4|
|Abstract: ||An HIV positive patient presenting a clinical picture of visceral
leishmaniasis co-infection was submitted to a bone marrow aspiration
after admission to hospital. Amastigotes forms were seen in the bone
marrow aspirate and the parasite grew in culture as promastigotes.
Molecular analyses showed that the flagellates isolated did not belong
to the genera Leishmania, Trypanosoma or Sauroleishmania. It was not
possible to establish infection in laboratory animals. In vitro culture
of mouse peritoneal macrophages revealed the invasion of the host cells
by the flagellates and their killing 48 hr after infection.
Opportunistic infection with an insect trypanosomatid was suspected.
Further hybridization analyses against a pannel of different monoxenous
and heteroxenous trypanosomatids showed kDNA cross-homology with
Leptomonas pulexsimulantis a trypanosomatid found in the dog's flea.
|Other Identifiers: ||http://www.bioline.org.br/abstract?id=oc98103|
|Rights: ||Copyright 1998 Fundacao Oswaldo Cruz - Fiocruz|
|Appears in Collections:||Bioline International Legacy Collection|