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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/22007

Title: Parasite Genotypically Related to a Monoxenous Trypanosomatid of Dog's Flea Causing Opportunistic Infection in an HIV Positive Patient
Authors: Pacheco, Raquel S.
Marzochi, Mauro C. A.
Pires, Marize Quinhones
Brito, Celia Maria Marques
Madeira, Maria de Fatima
Barbosa-Santos, Elizabeth Gloria Oliveira
Keywords: opportunistic infection - AIDS - monoxenous trypanosomatid - minicircle - hybridization
Issue Date: 31-Dec-1998
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 93 Num 4
Abstract: An HIV positive patient presenting a clinical picture of visceral leishmaniasis co-infection was submitted to a bone marrow aspiration after admission to hospital. Amastigotes forms were seen in the bone marrow aspirate and the parasite grew in culture as promastigotes. Molecular analyses showed that the flagellates isolated did not belong to the genera Leishmania, Trypanosoma or Sauroleishmania. It was not possible to establish infection in laboratory animals. In vitro culture of mouse peritoneal macrophages revealed the invasion of the host cells by the flagellates and their killing 48 hr after infection. Opportunistic infection with an insect trypanosomatid was suspected. Further hybridization analyses against a pannel of different monoxenous and heteroxenous trypanosomatids showed kDNA cross-homology with Leptomonas pulexsimulantis a trypanosomatid found in the dog's flea. {P}
URI: http://hdl.handle.net/1807/22007
Other Identifiers: http://www.bioline.org.br/abstract?id=oc98103
Rights: Copyright 1998 Fundacao Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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