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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/22070

Title: Partial Protection of Mice against Trypanosoma cruzi after Immunizing with the TcY 72 Antigenic Preparation
Authors: Gomes, Yara M.
Abath, Frederico Guilherme Coutinho
Nakazawa, Mineo
Minoprio, Paola
Vouldoukis, Ioannis
Monjour, Loic
Keywords: Trypanosoma cruzi - immunization - TcY antigenic preparation - Chagas' disease
Issue Date: 31-Dec-1999
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 94 Num 2
Abstract: A 72 kDa Trypanosoma cruzi glycoprotein recognized by the 164C11 monoclonal antibody (IgM isotype) was purified by preparative electrophoresis. The antigenic preparation obtained, named TcY 72, was used to immunize C57Bl/10 mice. The following results were observed after immunization: (1) induction of higher titres of IgG than IgM antibodies, as evaluated by indirect immunofluorescence; (2) significant DTH after injection of epimastigotes in mice footpads; (3) peak parasitemia in immunized mice was significantly reduced and animals were negative by 13 days post-infection, although the mice still succumb to infection; (4) the phenotypic analysis of spleen cell populations showed a decrease in the CD4/CD8 ratio in immunized mice. Taken as a whole, these findings indicate that TcY 72 is immunogenic and potentially important for protective immunity.
URI: http://hdl.handle.net/1807/22070
Other Identifiers: http://www.bioline.org.br/abstract?id=oc99032
Rights: Copyright 1999 Fundacao Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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