|Title: ||Hemagglutinating and Fusogenic Activities of Newcastle Disease Virus: Studies on Receptor Binding Specificity and pH-induced Conformational Changes|
|Authors: ||Couceiro, E. S. S.|
Couceiro, N. S. S.
Cabral, M. C.
|Keywords: ||Newcastle Disease virus - hemagglutinin - neuraminidase - fusion
protein - variants|
|Issue Date: ||31-Dec-1995|
|Publisher: ||Fundação Oswaldo Cruz, Fiocruz|
|Citation: ||Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 90 Num 4|
|Abstract: ||Vaccinal and wild strains of Newcastle Disease virus (NDV) were
analyzed for cell receptor binding and fusogenic biological properties
associated with their HN (hemagglutimn-neuraminidase) and F (fusion
protein) surface structures respectively. The evaluation of the
biological activities of HN and F was carried out respectively by
deterntination of hemagglutinating titers and hemolysis percentages,
using erythrocytes from various animal origins at different pH values.
Significant differences in hemag-glutination titersfor some strains of
NDV were detected, when interacting with goose, sheep, guineapig and
human "O" group erythrocytes at neutral pH. Diversity of hemolysis
percentages was observed between different NDV strains at acid pH.
These analysis were developed to evaluate particular aspects of the
actual influence of the receptor specificity and pH on the receptor
binding and fusogenic processes of Newcastle Disease viruses.|
|Other Identifiers: ||http://www.bioline.org.br/abstract?id=oc95102|
|Rights: ||Copyright 1995 Fundacao Oswaldo Cruz|
|Appears in Collections:||Bioline International Legacy Collection|