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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/22123


Title: Tuberculin skin test and CD4+/CD8+ T cell counts in adults infected with the human immunodeficiency virus in Medellin, Colombia
Authors: Rodriuez, J. I.
Arias, M.
Paris, S. C.
Arbelaez, M. P.
Betancur, J.
Garcia, L. F.
Keywords: HIV - tuberculin - BCG vaccination - CD4 - CD8
Issue Date: 31-Dec-1997
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 92 Num 2
Abstract: To evaluate the effect of BCG vaccination and T lymphocyte subpopulations on the reactivity to the tuberculin skin test, 113 asymtomatic HIV+ individuals were tuberculin tested by intradermal injection of 5TU of purified protein derivative and the levels of circulating lymphocyte (CD3, CD4 and CD8) subpopulations determined by indirect immunofluorescence. Ninety-two percent of the subjects included in the study were males. The mean age of the group was 32.1+/-7.4 years. Sixty-two percent presented a BCG scar. However, only 22% exhibited positive tuberculin reactions (}5mm) irrespective of the presence of the BCG scar. Tuberculin positive individuals exhibited higher CD4+ cell counts (p=0.004) and CD4+/CD8+ ratios (p=0.006) than tuberculin negative ({5mm) HIV+ individuals. The number of individuals with positive tuberculin reactions was significantly higher in subjects with more than 500 CD4+ lymphocytes/ml (p=0.02) or CD4+/CD8+ ratios }1.12 (p=0.002). These results suggest that a prior BCG vaccination does not influence the reactivity to the tuberculin skin test in HIV+ asymptomatic individuals and that the number of CD4+ lymphocytes and the CD4+/CD8+ ratio positively correlate with the tuberculin reactivity.
URI: http://hdl.handle.net/1807/22123
Other Identifiers: http://www.bioline.org.br/abstract?id=oc97048
Rights: Copyright 1997 Fundacao Oswaldo Cruz
Appears in Collections:Bioline International Legacy Collection

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