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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/22280

Title: Painful neuropathy in H.I.V. patients: its response to oral prednisolone
Issue Date: 31-Dec-1995
Publisher: Pan African Association of Neurological Sciences
Citation: African Journal of Neurological Sciences (ISSN: 1015-8618) Vol 14 Num 2
Abstract: The African Journal of Neurological Sciences Vol 14 No.2 1995 Painful neuropathy in H.I.V. patients: its response to oral prednisolone A.M.Adam Code Number: NS95008 Size of Files: Text: 17.2K Graphics: Line drawing (gif) - 3.5K SUMMARY Painful neuropathies due to any diseases, cause a lot of morbidity since in most cases they respond poorly to various therapies. It was decided to study the clinical features, electrophysiology and response to a short course of oral prednisolone in H.I.V. patients. Between 1988 and 1992 seven cases of neuropathies presenting primarily as a painful syndrome in Human Immunodeficiency Virus positive patients were seen in Nairobi, Kenya there were five males and two females. Their age ranged from 45 to 57 years. Four patients had their H.I.V. diseases presenting for the first time as a painful neoropathy. They did not have any clinical feature to suggest related acquired Immunodeficiy state. The other three patients were known H.I.V. related acquired immunodeficiency cases (AIDS). Two of these AIDS cases had neurophysiological evidence of diffuse sensory neuropathy of axonal type. In the rest of the patients nerve conduction studies were normal. All patients had been given various analgesics with carbamazephine and amytryptilline without response. None were given narcotic analgesics. All patients were first given placebo for one week followed by Oral prednisolone at 0.6mg/kg daily. There was no response to placebo but there was remarkable resolution of pain within one week of oral prednisolone. Therefore a short course of oral prednisolone is useful in the short term management of painful H.I.V. neuropathy. RESUME Les neuropathies douloureuses liees a certaines maladies sont la cause d'une morbidite importante, et repondent mal a de nombreuses therapies. Il a ete decide d'etudier les caracteristiques cliniques, electrophysiologiques et les reponses a un traitement de courte duree par la prednisolone chez les patients seropositifs pour le VIH. Entre 1988 et 1992, 7 cas de VIH (5 hommes et 2 femmes) presentant une neuropathie douloureuse ont ete suivis a Nairobi, Kenya. Leu age variait entre 45 et 57 ans; chez 4 de ces patients le premier signe de la maladie etait une neuropathie douloureuse; il n'existait aucune caracteristique povant suggerer le stade du sydrome d'immunodeficience acquise (SIDA). Les 3 autres patients etaient connus comme ayant un SIDA; 2 de ces patients avaient une neuropathie sensitive diffuse de type axonal, caracteristique a l'examen neurophysiologique. Les enregistrements des vitesses de conduction etaient normaux chez les autres patients. Tous les patients ont ete traites par des analgesiques associes a la carbamazepine et a l'amytryptilline, mais sans resultat favorable. Aucun n'a pris d'analgesique narcotique. Tous les patients ont d'abord ete traites par placebo pendant une semaine, puis par un traitement oral de prednisolone a la dose de 0,6 mg/kg/jour. Il n'y a pas eu de reponse favorable au placebo, mais une remarquable resolution de la douleur avant la fin de la premiere semaine de traitement oral par la prednisolone. Par consequent, un court traitement oral par la prednisolone est utile a court terme dans la prise en charge de la neuropathie douloreuse du VIH. Key Words: Neuropathy - HIV - PAIN - PREDNISOLONE Copyright 1995 Pan African Association of Neurological Sciences
URI: http://hdl.handle.net/1807/22280
Other Identifiers: http://www.bioline.org.br/abstract?id=ns95008
Rights: Copyright 1995 Pan African Association of Neurological Sciences
Appears in Collections:Bioline International Legacy Collection

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