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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/22413


Title: Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain
Authors: Pacheco, Raquel S.
Ferreira, Marcelo Simão
Machado, Maria Ines
Brito, Celia Maria Marques
Pires, Marize Quinhones
Da-Cruz, Alda M.
Coutinho, Sérgio G.
Keywords: Chagas' disease/AIDS co-infection - opportunistic infection - Trypanosoma cruzi - reactivation
Issue Date: 31-Dec-1998
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 93 Num 2
Abstract: In the past few years, new aspects of the immunopathology of Chagas' disease have been described in immunosuppressed patients, such as fatal central nervous system lesions related to the reactivation of the parasite. This article is the first description of the genotypic characterization, at the strain level, of Trypanosoma cruzi isolated from a patient with Chagas` disease/AIDS co-infection. The presence of four hypodense lesions was observed in the cranial compute tomographic scan. The diagnosis of AIDS was assessed by the detection of anti-HIV antibodies using enzyme-linked immunosorbent assay (ELISA) and Western blot techniques. The CD4^+ lymphocyte counts were maintained under 200 cells/mm^3 during one year demonstrating the severity of the state of immunosuppression. Chagas' disease was confirmed by serological and parasitological methods. Trypomastigote forms were visualized in a thick blood smear. The parasite isolated is genotypically similar to the CL strain. The paper reinforces that cerebral Chagas' disease can be considered as another potential opportunistic infection in AIDS resulting from the reactivation of a dormant T. cruzi infection acquired years earlier.
URI: http://hdl.handle.net/1807/22413
Other Identifiers: http://www.bioline.org.br/abstract?id=oc98030
Rights: Copyright 1998 Fundacao Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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