|Title: ||Hypertrophic Cardiomyopathy: An Autopsy Analysis of 14 Cases|
|Authors: ||Phadke, R. S.|
|Keywords: ||Myofibre disarray, Obliterative small vessel disease, Sudden death|
|Issue Date: ||31-Dec-2001|
|Publisher: ||Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India|
|Citation: ||Journal of Postgraduate Medicine (ISSN: 0972-2823) Vol 47 Num 3|
|Abstract: ||BACKGROUND: Hypertrophic cardiomyopathy (HCM) is one of the less common
forms of primary cardiomyopathies. There is little data available on
HCM in Indian literature. AIMS: To assess the incidence and analyse the
clinicopathological features of HCM. SETTINGS: Analysis of data of 15
years from a tertiary care centre. METHODS AND MATERIAL: The clinical
and pathological data in fourteen cases of HCM with respect to their
gross and microscopic features and clinical presentation were reviewed.
RESULTS: Incidence of HCM amongst the autopsied primary
cardiomyopathies (N = 101) was 13.9% (n=14). Males were affected more.
Common presenting symptoms were exertional dyspnoea, angina and
palpitations. Concentric and asymmetric hypertrophy was equally seen.
Obliterative small vessel disease was noted in 50% of the cases.
Although significant myofibre disarray (>5%) was seen in all
fourteen cases, it could be demonstrated in only 40- 50% of an average
of twenty sections studied. Type IA myofibre disarray was the
commonest. Six of the fourteen patients died suddenly. Cardiac failure
was the commonest cause of death. CONCLUSIONS: Myofibre disarray is a
highly sensitive and specific marker for HCM only when considered in a
quantitative rather than a qualitative fashion. In this context, the
rationale for performing endomyocardial biopsy is to rule out mimics of
|Other Identifiers: ||http://www.bioline.org.br/abstract?id=jp01048|
|Rights: ||Copyright 2001 Journal of Postgraduate Medicine. Online full text also
|Appears in Collections:||Bioline International Legacy Collection|