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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/22617

Title: SHORT COMMUNICATION - Recent Advances in the Diagnosis of Schistosoma Infection: the Detection of Parasite DNA
Authors: Rabello, Ana Lúcia Teles
Pontes, Luís André
Dias-Neto, Emmanuel
Keywords: schistosomiais - diagnosis - polymerase chain reaction
Issue Date: 31-Dec-2002
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 97 Num s1
Abstract: As Schistosoma   sp. control programs are chiefly based on treatment of infected population, adequate case finding has a crucial role. The available diagnostic methods are far from ideal, since the search for eggs in stools and the detection of circulating antigens lack sensitivity in low prevalence and post-treatment situations and antibody detection lacks specificity. In most endemic foci, repeated treatment of infected people leaves a number of non-diagnosed and consequently non-treated persons, enough to maintain a persistent residue of 5 to 10% prevalence. In an attempt to surpass these diagnostic limitations we have developed a polymerase chain reaction (PCR) for the detection of Schistosoma sp. in feces that, in a first population study, has shown to be more sensitive than three-repeated stool Kato-Katz examination. The PCR may constitute a valuable tool for the diagnosis of the Schistosoma sp. infection in special situations, when high sensitivity and specificity are required and infrastructure is available.
URI: http://hdl.handle.net/1807/22617
Other Identifiers: http://www.bioline.org.br/abstract?id=oc02208
Rights: Copyright 2002 - Instituto Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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