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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/22770


Title: Apoptosis as a Target for Gene Therapy in Rheumatoid Arthritis
Authors: Rabinovich, Gabriel Adrián
Keywords: apoptosis, gene therapy, rheumatoid arthritis, galectin-1
Issue Date: 31-Dec-2000
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 95 Num s1
Abstract: Rheumatoid arthritis (RA) is characterized by chronic inflammation of the synovial joints resulting from hyperplasia of synovial fibroblasts and infiltration of lymphocytes, macrophages and plasma cells, all of which manifest signs of activation. All these cells proliferate abnormally, invade bone and cartilage, produce an elevated amount of pro-inflammatory cytokines, metalloproteinases and trigger osteoclast formation and activation. Some of the pathophysiological consequences of the disease may be explained by the inadequate apoptosis, which may promote the survival of autoreactive T cells, macrophages or synovial fibroblasts. Although RA does not result from single genetic mutations, elucidation of the molecular mechanisms implicated in joint destruction has revealed novel targets for gene therapy. Gene transfer strategies include inhibition of pro-inflammatory cytokines, blockade of cartilage-degrading metalloproteinases, inhibition of synovial cell activation and manipulation of the Th1-Th2 cytokine balance. Recent findings have iluminated the idea that induction of apoptosis in the rheumatoid joint can be also used to gain therapeutic advantage in the disease. In the present review we will discuss different strategies used for gene transfer in RA and chronic inflammation. Particularly, we will highlight the importance of programmed cell death as a novel target for gene therapy using endogenous biological mediators, such as galectin-1, a b-galactoside-binding protein that induces apoptosis of activated T cells and immature thymocytes.
URI: http://hdl.handle.net/1807/22770
Other Identifiers: http://www.bioline.org.br/abstract?id=oc00186
Rights: Copyright 2000 Fundacao Oswaldo Cruz Fiocruz
Appears in Collections:Bioline International Legacy Collection

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