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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/22941

Title: Hepatitis C and Hepatitis B Virus Infection in Different Hemodialysis Units in Belo Horizonte, Minas Gerais, Brazil
Authors: Busek, Solange U.
Babá, Élio H.
Filho, Hélcio A. Tavares
Pimenta, Lermíno
Salomão, Abraão
Corrêa-Oliveira, Rodrigo
Oliveira, Guilherme C.
Keywords: alanine aminotransferase - hepatitis C virus genotype - hemodialysis - hepatitis B - hepatitis C - prevalence - Belo Horizonte - Brazil
Issue Date: 31-Dec-2002
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 97 Num 6
Abstract: The prevalence, virological and epidemilogical aspects of the hepatitis C virus (HCV) and the hepatitis B virus (HBV) infections vary among hemodialysis patients in different countries. Aiming at analyzing these aspects of HCV and HBV infections in hemodialysis patients in Belo Horizonte, MG, Brazil, we studied three hemodialysis units including 434 patients. Serology was used to detect anti-HCV and HBsAg. Reverse trancriptase nested polymerase chain reaction (RT-nested-PCR) of the 5'-noncoding region was used to detect circulating HCV RNA and restriction fragment length polymorphism analysis for genotyping. Seroprevalence varied from 26.5% to 11.1% for hepatitis C and from 5.9% to 0% for hepatitis B. Risk factors observed for HBV and/or HCV infections were the number of patients per dialysis unit, duration of treatment, number of clinics attended, number of blood units transfused, and lower level scholarity. Alanine aminotransferase levels were altered with a higher frequency in HBV or HCV seropositive patients. Half of ten patients, negative for anti-HCV, had detectable viremia by RT-nested-PCR, indicating that this technique should be used to confirm infections in this group of patients. The HCV genotype 1 was the most frequently observed, followed by the genotype 2, but no correlation was detected between genotype and clinical or epidemiological data.
URI: http://hdl.handle.net/1807/22941
Other Identifiers: http://www.bioline.org.br/abstract?id=oc02148
Rights: Copyright 2002 - Instituto Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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