|Title: ||A Long-term Intake of a Protein Hydrolysate Seems to Increase the Risk of Encephalopathy in Mice Infected with Schistosoma mansoni|
|Authors: ||Ferreira, Haroldo S.|
Coutinho, Eridan M.
Nascimento, Graciliano Ramos A.
Carvalho, Mônica C.
|Keywords: ||schistosomiasis - undernutrition - aminoacids absorption - hydrolysed
|Issue Date: ||31-Dec-1998|
|Publisher: ||Fundação Oswaldo Cruz, Fiocruz|
|Citation: ||Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 93 Num s1|
|Abstract: ||Previous investigations showed that Schistosoma mansoni infection
aggravates protein malabsorption in undernourished mice and this can be
reverted by administration of casein hydrolysate. The present study was
undertaken to evaluate the effects of ingestion of casein hydrolysate
for long periods. Albino Swiss mice were divided into eight groups.
Diets contained 5% (undernourished ) or 20% (controls) casein levels.
For each group there were sub-groups ingesting whole or hydrolysed
casein for 12 weeks. Infection with S. mansoni developed in half of the
animals under each diet. All undernourished mice developed
malabsorption. Low albuminemia was detected in infected animals
independently of the protein level in the diet. However, albuminemia
was lower in infected controls than in undernourished non-infected
mice, suggesting a deficient liver protein synthesis. Infected mice fed
on a 20% protein hydrolysed diet exhibited low weight gain and high
mortality rates. On the other hand, non-infected mice ingesting the
same diet had the highest body weights. We are investigating the
hypothesis that infected mice, even when fed normal diets, are unable
to metabolise large amounts of amino acids due to the liver lesions
related to schistosomiasis and as a result die of hepatic coma. In some
of them, the excessive accumulation of ammonia in the blood enhances
the outcome of an encephalopathy.|
|Other Identifiers: ||http://www.bioline.org.br/abstract?id=oc98167|
|Rights: ||Copyright 1998 Fundacao Oswaldo Cruz - Fiocruz|
|Appears in Collections:||Bioline International Legacy Collection|