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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/23035

Title: A Long-term Intake of a Protein Hydrolysate Seems to Increase the Risk of Encephalopathy in Mice Infected with Schistosoma mansoni
Authors: Ferreira, Haroldo S.
Coutinho, Eridan M.
Nascimento, Graciliano Ramos A.
Carvalho, Mônica C.
Keywords: schistosomiasis - undernutrition - aminoacids absorption - hydrolysed casein
Issue Date: 31-Dec-1998
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 93 Num s1
Abstract: Previous investigations showed that Schistosoma mansoni infection aggravates protein malabsorption in undernourished mice and this can be reverted by administration of casein hydrolysate. The present study was undertaken to evaluate the effects of ingestion of casein hydrolysate for long periods. Albino Swiss mice were divided into eight groups. Diets contained 5% (undernourished ) or 20% (controls) casein levels. For each group there were sub-groups ingesting whole or hydrolysed casein for 12 weeks. Infection with S. mansoni developed in half of the animals under each diet. All undernourished mice developed malabsorption. Low albuminemia was detected in infected animals independently of the protein level in the diet. However, albuminemia was lower in infected controls than in undernourished non-infected mice, suggesting a deficient liver protein synthesis. Infected mice fed on a 20% protein hydrolysed diet exhibited low weight gain and high mortality rates. On the other hand, non-infected mice ingesting the same diet had the highest body weights. We are investigating the hypothesis that infected mice, even when fed normal diets, are unable to metabolise large amounts of amino acids due to the liver lesions related to schistosomiasis and as a result die of hepatic coma. In some of them, the excessive accumulation of ammonia in the blood enhances the outcome of an encephalopathy.
URI: http://hdl.handle.net/1807/23035
Other Identifiers: http://www.bioline.org.br/abstract?id=oc98167
Rights: Copyright 1998 Fundacao Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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