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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/23109


Title: Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review
Issue Date: 31-Dec-2001
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 96 Num 1
Abstract: Mem Inst Oswaldo Cruz 2001, Volume 96, Number 1, pp. 1-14 Vertical Human Immunodeficiency Virus Type 1 - HIV-1 -Transmission - A Review Vera Bongertz Code Number: oc01001 ABSTRACT: Several factors appear to affect vertical HIV-1 transmission, dependent mainly on characteristics of the mother (extent of immunodeficiency, co-infections, risk behaviour, nutritional status, immune response, genetical make-up), but also of the virus (phenotype, tropism) and, possibly, of the child (genetical make-up). This complex situation is compounded by the fact that the virus may have the whole gestation period, apart from variable periods between membrane rupture and birth and the breast-feeding period, to pass from the mother to the infant. It seems probable that an extensive interplay of all factors occurs, and that some factors may be more important during specific periods and other factors in other periods. Factors predominant in protection against in utero transmission may be less important for peri-natal transmission, and probably quite different from those that predominantly affect transmission by mothers milk. For instance, cytotoxic T lymphocytes will probably be unable to exert any effect during breast-feeding, while neutralizing antibodies will be unable to protect transmission by HIV transmitted through infected cells. Furthermore, some responses may be capable of controlling transmission of determined virus types, while being inadequate for controlling others. As occurence of mixed infections and recombination of HIV-1 types is a known fact, it does not appear possible to prevent vertical HIV-1 transmission by reinforcing just one of the factors, and probably a general strategy including all known factors must be used. Recent reports have brought information on vertical HIV-1 transmission in a variety of research fields, which will have to be considered in conjunction as background for specific studies. KEYWORDS: HIV, vertical HIV-1 transmission Copyright 2001 Fundacao Oswaldo Cruz Fiocruz
URI: http://hdl.handle.net/1807/23109
Other Identifiers: http://www.bioline.org.br/abstract?id=oc01001
Rights: Copyright 2001 Fundação Oswaldo Cruz, Fiocruz
Appears in Collections:Bioline International Legacy Collection

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