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T-Space at The University of Toronto Libraries >
Medical Biophysics (MBP) >
Thermal Therapy >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/2327

Title: Cellular effects of hyperthermia: relevance to the minimum dose for thermal damage
Authors: Lepock, James R., lepock_at_uhnres.utoronto.ca
Keywords: Arrhenius plot
cellular effects
cell killing
heat shock response
induced hyperthermia
physical therapy techniques
protein aggregation
protein denaturation
therapeutics
thermotolerance
Issue Date: May-2003
Publisher: Taylor & Francis (www.tandf.co.uk/journals)
Citation: International Journal of Hyperthermia 2003(May/June); 19(3): 252-266
Abstract: The specific mechanism of cell killing by hyperthermia is unknown, but the high activation energy of cell killing and other responses to hyperthermia suggest that protein denaturation is the rate-limiting step. Protein denaturation can be directly monitored by differential scanning calorimetry and in general there is a good correlation between protein denaturation and cellular response. Approximately 5% denaturation is necessary for detectable killing. Protein denaturation leads to the aggregation of both denatured and native protein with multiple effects on cellular function.
Description: A review of the cellular effects of hyperthermia. The Permissions Administrator (UK) Journals, at Taylor & Francis Ltd., granted entirely free permission to reproduce this article, provided that the original source of publication is acknowledged and a reference to the Journal's web site is included. The former is: Int. J. Hyperthermia vol. 19, no. 3 (May-June 2003), pp. 252-266. The latter is: http://www.tandf.co.uk/journals
URI: http://hdl.handle.net/1807/2327
ISSN: 1464-5157 online
0265-6736 print
Appears in Collections:Thermal Therapy

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