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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/23570

Title: Autotransplant of Spleen Tissue in Children with Schistosomiasis: Evaluation of Splenic Function after Splenosis
Authors: Brandt, Carlos Teixeira
Maciel, Dione Tavares
Caneca, Oyama Arruda Frei
Barbosa de Castro, Célia Maria Machado
Bragante de Araújo, Lenísio
Keywords: spleen tissue autotransplantation, splenosis, Schistosoma mansoni splenic functions, tuftsin, pneumococcal vaccine response
Issue Date: 31-Dec-2001
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 96 Num S1
Abstract: Autotransplantation of spleen tissue has been done, in the past ten years, in children with schistosomiasis mansoni with bleeding varices. The purposes of this investigation were: (1) to study the morphology and function of the remnant spleen tissue; (2) to quantify the production of tuftsin; and (3) to assess the immune response to pneomococcal vaccine of these patients. Twenty three children, who underwent splenectomy and autologous implantation of spleen tissue into the greater omentum were included in this investigation. The average postoperative follow-up is five years. Splenosis was proved by colloid liver-spleen scans. Search for Howell-Jolly bodies assessed the filtration function. Tuftsin and the titer of pneumococcal antibodies were quantified by ELISA. Splenosis was evident in all children; however, it was insufficient in two. Howell-Jolly bodies were found only in these two patients. The mean tuftsin serum concentration (335.0 ± 29.8 ng/ml) was inside the normal range. The immune response to pneumococcal vaccination was adequate in 15 patients; intermediate in four; and inadequate in four. From the results the following conclusions can be drawn: splenosis was efficient in maintaining the filtration splenic function in more than 90% and produced tuftsin inside the range of normality. It also provided the immunologic splenic response to pneumococcal vaccination in 65% of the patients of this series.
URI: http://hdl.handle.net/1807/23570
Other Identifiers: http://www.bioline.org.br/abstract?id=oc01161
Rights: Copyright 2001 Instituto Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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