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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/23695

Title: A GBP 130 Derived Peptide from Plasmodium falciparum Binds to Human Erythrocytes and Inhibits Merozoite Invasion in Vitro
Authors: Suarez, Jorge E.
Urquiza, Mauricio
Curtidor, Hernando
Rodriguez, Luis E.
Ocampo, Marisol
Torres, Elizabeth
Guzman, Fanny
Patarroyo, Manuel Elkin
Keywords: Plasmodium falciparum, GBP 130, binding assay
Issue Date: 31-Dec-2000
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 95 Num 4
Abstract: The malarial GBP 130 protein binds weakly to intact human erythrocytes; the binding sites seem to be located in the repeat region and this region's antibodies block the merozoite invasion. A peptide from this region (residues from 701 to 720) which binds to human erythrocytes was identified. This peptide named 2220 did not bind to sialic acid; the binding site on human erythrocyte was affected by treatment with trypsin but not by chymotrypsin. The peptide was able to inhibit Plasmodium falciparum merozoite invasion of erythrocytes. The residues F701, K703, L705, T706, E713 (FYKILTNTDPNDEVERDNAD) were found to be critical for peptide binding to erythrocytes.
URI: http://hdl.handle.net/1807/23695
Other Identifiers: http://www.bioline.org.br/abstract?id=oc00078
Rights: Copyright 2000 Fundacao Oswaldo Cruz Fiocruz
Appears in Collections:Bioline International Legacy Collection

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