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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/23846


Title: Vertical Toxoplasmosis in a Murine Model. Protection after Immunization with Antigens of Toxoplasma gondii Incorporated into Liposomes
Issue Date: 31-Dec-2001
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 96 Num 1
Abstract: Mem Inst Oswaldo Cruz 2001, Volume 96, Number 1, pp. 99-104 Vertical Toxoplasmosis in a Murine Model. Protection after Immunization with Antigens of Toxoplasma gondii Incorporated into Liposomes Mohamed MA Elsaid, Maria S Martins, Frdric Frzard*, Erika M Braga, Ricardo WA Vitor/+ Code Number: oc01011 ABSTRACT: Distinct Toxoplasma gondii antigens were entrapped within liposomes and evaluated for their ability to protect Balb/c mice against congenital transmission: soluble tachyzoite antigen (L/STAg), soluble tissue cyst antigen (L/SCAg), soluble tachyzoite plus tissue cyst (L/STCAg) or purified 32kDa antigen of tachyzoite (L/pTAg). Soluble tachyzoite antigen alone in PBS (STAg) or emulsified in Freund's Complete Adjuvant (FCA/STAg) was also evaluated. Dams were inoculated subcutaneously with these antigens 6, 4 and 2 weeks prior to a challenge with four tissue cysts of the P strain of T. gondii orally between 10 and 14 days of pregnancy. Significant diminution differences were observed between the frequency of infected pups born of the dams immunized with the antigens incorporated into liposomes and that of pups born of the dams immunized with antigen emulsified in FCA or non immunized group (p KEYWORDS: Toxoplasma, immunoprotection, congenital transmission, mice, liposomes Copyright 2001 Fundacao Oswaldo Cruz Fiocruz
URI: http://hdl.handle.net/1807/23846
Other Identifiers: http://www.bioline.org.br/abstract?id=oc01011
Rights: Copyright 2001 Fundação Oswaldo Cruz, Fiocruz
Appears in Collections:Bioline International Legacy Collection

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