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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/23905


Title: Selection, recombination and history in a parasitic flatworm (Echinococcus) inferred from nucleotide sequences
Authors: Haag, K. L.
Araújo, A. M.
Gottstein, B.
Zaha, A.
Keywords: Echinococcus - parasites - recombination - SSCP - sequencing - phylogeny
Issue Date: 31-Dec-1998
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 93 Num 5
Abstract: Three species of flatworms from the genus Echinococcus (E. granulosus, E. multilocularis and E. vogeli) and four strains of E. granulosus (cattle, horse, pig and sheep strains) were analysed by the PCR-SSCP method followed by sequencing, using as targets two non-coding and two coding (one nuclear and one mitochondrial) genomic regions. The sequencing data was used to evaluate hypothesis about the parasite breeding system and the causes of genetic diversification. The calculated recombination parameters suggested that cross-fertilisation was rare in the history of the group. However, the relative rates of substitution in the coding sequences showed that positive selection (instead of purifying selection) drove the evolution of an elastase and neutrophil chemotaxis inhibitor gene (AgB/1). The phylogenetic analyses revealed several ambiguities, indicating that the taxonomic status of the E. granulosus horse strain should be revised.
URI: http://hdl.handle.net/1807/23905
Other Identifiers: http://www.bioline.org.br/abstract?id=oc98132
Rights: Copyright 1998 Fundacao Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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