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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24090

Title: Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches
Authors: Lenzi, Henrique L.
Kimmel, Eitan
Schechtman, Helio
Pelajo-Machado, Marcelo
Romanha, Waldemiro S.
Pacheco, Ronaldo G.
Mariano, Mario
Lenzi, Jane A.
Keywords: Schistosoma mansoni - granuloma - biomechanics - fibrosis - extracellular matrix - laser confocal microscopy
Issue Date: 31-Dec-1998
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 93 Num s1
Abstract: The authors present morphogenetic and biomechanical approaches on the concept of the Schistosoma mansoni granulomas, considering them as organoid structures that depend on cellular adhesion and sorting, forming rearrangement into hierarchical concentric layers, creating tension-dependent structures, aiming to acquire round form, since this is the minimal energy form, in which opposing forces pull in equally from all directions and are in balance. From the morphogenetic point of view, the granulomas function as little organs, presenting maturative and involutional stages in their development with final disappearance (pre-granulomatous stages, subdivided in: weakly and/or initial reactive and exudative; granulomatous stages: exudative-productive, productive and involutional). A model for the development of granulomas was suggested, according to the following stages: encapsulating, focal histolysis, fiber production, orientation and compacting and involution and desintegration. The authors concluded that schistosomal granuloma is not a tangled web of individual cells and fibers, but an organized structure composed by host and parasite components, which is not formed to attack the miracidia, but functions as an hybrid interface between two different phylogenetic beings.
URI: http://hdl.handle.net/1807/24090
Other Identifiers: http://www.bioline.org.br/abstract?id=oc98153
Rights: Copyright 1998 Fundacao Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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