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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24241

Title: Nitric Oxide as a Marker of Smoking Abstinence
Authors: Barreto, Renata
Advisor: Chapman, Kenneth
Department: Medical Science
Keywords: nitric oxide
Issue Date: 6-Apr-2010
Abstract: Introduction: To evaluate the effectiveness of smoking cessation intervention, reliable outcome is essential. Exhaled nitric oxide (ENO) is decreased in smokers, tends to normalize after cessation and might be a good tool to evaluate abstinence. Objective: To evaluate changes in ENO after smoking abstinence of 7 or more days. Methods: 58 smokers in a cessation attempt and 12 non-smokers were recruited: 7 visits for smokers and 2 for non-smokers. Carbon monoxide and cotinine were used to detect smoking status. Results: ENO is decreased in smokers compared to non-smokers (10.8 vs. 20.1 ppb, p<0.001). There was no significant difference in ENO pre and post quitting (p=0.080) although there was a trend to increase as early as 3 days after abstinence (10.78 vs. 15.11, p>0.05). There were no differences in nasal NO measurements (p=0.278). Conclusion: ENO doesn’t seem to be a reliable marker of short-term abstinence.
URI: http://hdl.handle.net/1807/24241
Appears in Collections:Master
Institute of Medical Science - Master theses

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