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T-Space at The University of Toronto Libraries >
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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24259

Title: Flow-based Organization of Perfusable Soft Material in Three Dimensions
Authors: Leng, Lian
Advisor: Guenther, Axel
Department: Mechanical and Industrial Engineering
Keywords: microfluidics
multilayer
3D
soft material
vascularized
perfusable
tunable
tissue engineering
Issue Date: 6-Apr-2010
Abstract: This thesis presents a microfluidic strategy for the in-flow definition of a 3D soft material with a tunable and perfusable microstructure. The strategy was enabled by a microfluidic device containing up to fifteen layers that were individually patterned in polydimethylsiloxane (PDMS). Each layer contained an array of ten to thirty equidistantly spaced microchannels. Two miscible fluids (aqueous solutions of alginate and CaCl2) were used as working fluids and were introduced into the device via separate inlets and distributed on chip to form a complex fluid at the exit. The fluid microstructure was tuned by altering the flow rates of the working fluids. Upon solidification of alginate in the presence of calcium chloride, the created microstructure was retained and a soft material with a tunable microstructure was formed. The produced material was subsequently perfused using the same microfluidic architecture. The demonstrated strategy potentially offers applications in materials science and regenerative medicine.
URI: http://hdl.handle.net/1807/24259
Appears in Collections:Master
Department of Mechanical & Industrial Engineering - Master theses

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