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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24266

Title: The Role of Rac1 and Rac2 in Determining Bone Quality in Aged and Osteoporotic Female Mouse Models
Authors: Magalhaes, Joyce Kellen Rodrigues de Souza
Advisor: Glogauer, Michael
Grynpas, Marc D.
Department: Dentistry
Keywords: Rac GTPases
bone remodeling
osteoclastogenesis
bone quality
Issue Date: 6-Apr-2010
Abstract: The osteoclasts, the bone cells responsible for bone degradation, have a crucial role in the age-related bone loss and post-menopause osteoporosis. Rac1 and Rac2, members of the Rho-family of small GTPases, are known for having a key role in osteoclast formation and activity, which could be translated to bone quality. In this study, we characterize the roles of Rac1 and Rac2 on bone quality using an aged and osteoporotic mouse model. Bones from wild type, Rac1KO and Rac2KO mice were harvested for mechanical tests, bone densitometry, micro-computed tomography and histomorphometric analyses to evaluate bone mineralization and architecture. We observed that the deletion of Rac1 or Rac2 in pre-osteoclasts minimized bone loss in both age-related and post-menopause osteoporosis. These results highlight the importance of the two small GTPases in bone remodeling and identify Rac1 and Rac2 as potential targets for the development of new therapies for the treatment of osteoporosis.
URI: http://hdl.handle.net/1807/24266
Appears in Collections:Master
Faculty of Dentistry - Master theses

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