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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24529

Title: The Effect of Helicobacter pylori on Innate Immunity
Authors: Ang, Michelle
Advisor: Jones, Nicola L.
Department: Physiology
Keywords: H. pylori
Immunity
STAT3
Dendritic Cell
Autophagy
VacA
ROS
Parkin
Issue Date: 21-Jul-2010
Abstract: The innate immune system is important in both acute and chronic infection. In this thesis, I investigated the effect of H. pylori infection on 1) DCs, key orchestrators of the immune system, and 2) autophagy, recently identified as an important component of innate immunity. I determined that H. pylori activates the STAT3 pathway in DCs, increasing DC maturation and inducing production of IL-10, IL-12p40 and TNF-α, without IL-12p70. This cytokine profile may favour an immunoregulatory response, promoting persistent H. pylori infection. In addition I determined that H. pylori’s VacA toxin induced autophagy, ROS production and Parkin aggregation which has been implicated in mediating autophagy in response to mitochondrial damage. Thus H. pylori alters these key effectors of innate immunity which may play a role in promoting its chronic infection and disease.
URI: http://hdl.handle.net/1807/24529
Appears in Collections:Master
Department of Physiology - Master theses

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