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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24548

Title: Synthesis and Application of Polymer Stabilized Lanthanide Fluoride Nanoparticles
Authors: Cheung, Evelyn
Advisor: Prosser, Robert Scott
Department: Biochemistry
Keywords: lanthanide fluoride nanoparticle aggregates
folic acid
magnetic resonance imaging
contrast agents
targeted imaging
Issue Date: 22-Jul-2010
Abstract: A new class of polymer coated lanthanide fluoride nanoparticle aggregates (NPAs) was developed as potential MRI contrast agents. The NPA synthesis has been perfected to control the size distribution and optimize relaxivities. Polyacrylic acid was used as a stabilizing polymer, and was conjugated to folic acid to improve targeting to SK-BR-3 breast cancer cells. Terbium was incorporated in the synthesis to study the passive and active targeting properties of NPAs. Through a series of microscopy experiments, a significant difference in uptake between NPAs with and without targeting moieties occurs after 48 hours of incubation. The relaxivity of the optimized nanoparticles was measured to be 56 s-1(mg/ml)-1 using a 1.5 T scanner, which may be compared to that of the commercially available Gd3+-DTPA [R1 = 7 s-1(mg/ml)-1]. Abdominal perfusion studies in rats also demonstrated that the NPAs provide better contrast of the vasculature than Gd3+-DTPA does at the same mass concentration.
URI: http://hdl.handle.net/1807/24548
Appears in Collections:Master
Department of Biochemistry - Master theses

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