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|Title: ||Oxidative Stress and Risk of Cardiovascular Disease Associated with Low- and High-monounsaturated Fat Portfolio Diets|
|Authors: ||Chiavaroli, Laura|
|Advisor: ||Jenkins, David J. A.|
|Department: ||Nutritional Sciences|
|Keywords: ||oxidative stress|
|Issue Date: ||22-Jul-2010|
|Abstract: ||The objective was to assess the effect of a high-monounsaturated fat (MUFA) dietary portfolio of cholesterol-lowering foods on oxidative stress and cardiovascular risk. Twenty-four hyperlipidemic subjects followed a very low-saturated-fat therapeutic control diet for 4 weeks after which they were randomized to receive the dietary portfolio, consisting of soy protein (20g/1000kcal), viscous fibre (10.3g/1000kcal), plant sterols (2-3g) and almonds (21.5g/1000kcal), in combination with high- or low-MUFA (25.9% and 12.9% MUFA, respectively) for the next 4 weeks, where MUFA replaced 13.0% of dietary carbohydrate.
On high-MUFA, there were significantly greater increases in HDL-C and apoA1 and significantly greater reductions in total:high-density lipoprotein cholesterol (total:HDL-C) ratio and high-sensitivity C-reactive protein (hs-CRP) compared to the low-MUFA dietary portfolio. In all diets there were significant increases in protein thiols and reductions in conjugated dienes and thiobarbituric acid reactive substances (TBARS) measured in the LDL-fraction, however no difference between the high- and low-MUFA diets.|
|Appears in Collections:||Master|
Department of Nutritional Sciences - Master theses
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