Home

Browse
Communities
& Collections

Issue Date
Author
Title
Subject

Sign on to:

My Account
authorized users

Edit Profile

Help
 Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24550

 Title: The Development of an Animal Model of Complicated Atherosclerosis for Non-invasive Imaging Authors: Chiu, Stephanie Elaine Gar-Wai Advisor: Moody, Alan Department: Medical Biophysics Keywords: Animal modelAtherosclerosisVessel wall diseaseMedical imagingMagnetic resonance imagingNeovascularization Issue Date: 22-Jul-2010 Abstract: The goal of this thesis was to produce an animal model that develops atherosclerotic plaque featuring plaque neovascularization leading to intraplaque hemorrhage and is suitable for noninvasive imaging studies. Several strategies were tested for their effectiveness in producing such plaques in the rabbit aorta, including: a high cholesterol diet, vascular endothelial growth factor injections, therapeutic contrast ultrasound, and balloon catheter injury. It was found that a combination of the high cholesterol diet and balloon injury was able to achieve plaque neovascularization in a manner dependent on circulating plasma cholesterol levels. In addition, a contrast-enhanced magnetic resonance imaging technique implemented in the animal model was able to detect plaque neovascularization and monitor its change over time in a single group of animals. In conclusion, an animal model was created where plaque neovascularization occurs in a predictable fashion and can be studied with non-invasive magnetic resonance imaging. URI: http://hdl.handle.net/1807/24550 Appears in Collections: MasterDepartment of Medical Biophysics - Master theses

Files in This Item:

File Description SizeFormat
View/Open