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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24550

Title: The Development of an Animal Model of Complicated Atherosclerosis for Non-invasive Imaging
Authors: Chiu, Stephanie Elaine Gar-Wai
Advisor: Moody, Alan
Department: Medical Biophysics
Keywords: Animal model
Atherosclerosis
Vessel wall disease
Medical imaging
Magnetic resonance imaging
Neovascularization
Issue Date: 22-Jul-2010
Abstract: The goal of this thesis was to produce an animal model that develops atherosclerotic plaque featuring plaque neovascularization leading to intraplaque hemorrhage and is suitable for noninvasive imaging studies. Several strategies were tested for their effectiveness in producing such plaques in the rabbit aorta, including: a high cholesterol diet, vascular endothelial growth factor injections, therapeutic contrast ultrasound, and balloon catheter injury. It was found that a combination of the high cholesterol diet and balloon injury was able to achieve plaque neovascularization in a manner dependent on circulating plasma cholesterol levels. In addition, a contrast-enhanced magnetic resonance imaging technique implemented in the animal model was able to detect plaque neovascularization and monitor its change over time in a single group of animals. In conclusion, an animal model was created where plaque neovascularization occurs in a predictable fashion and can be studied with non-invasive magnetic resonance imaging.
URI: http://hdl.handle.net/1807/24550
Appears in Collections:Master
Department of Medical Biophysics - Master theses

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