test Browse by Author Names Browse by Titles of Works Browse by Subjects of Works Browse by Issue Dates of Works

Advanced Search
& Collections
Issue Date   
Sign on to:   
Receive email
My Account
authorized users
Edit Profile   
About T-Space   

T-Space at The University of Toronto Libraries >
School of Graduate Studies - Theses >
Master >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24551

Title: Genetic Variation in Innate Immunity, Diet and Biomarkers of the Metabolic Syndrome
Authors: Cuda, Cristina Caterina
Advisor: El-Sohemy, Ahmed
Department: Nutritional Sciences
Keywords: Genetics
Toll-like receptor 4
Nucleotide binding oligomerization domain 1 and 2
dietary fat
metabolic syndrome
Issue Date: 22-Jul-2010
Abstract: Chronic low-grade inflammation is associated the Metabolic Syndrome (MetS) and may contribute to its development. A diet high in saturated fat (SFA) has been associated with increased inflammation and development of the MetS. SFAs have been shown to elicit pro-inflammatory signaling through proteins of innate immunity, TLR4 and Nods 1 and 2. We determined whether common polymorphisms in the genes of these proteins could modify the association between fat intake and biomarkers of the MetS. Fat intake was measured using a food frequency questionnaire and genotyping was completed using real-time PCR. The TLR4 Asp299Gly (rs4986790) polymorphism was associated with decreased insulin sensitivity while an intronic polymorphism (rs5030728) modified the association between dietary SFA and HDL-cholesterol. The Nod1 Glu266Lys polymorphism modified the association between dietary SFA and HOMA-IR. These results suggest a role for innate immunity in mediating some of the effects of dietary SFAs on factors associated with the MetS.
URI: http://hdl.handle.net/1807/24551
Appears in Collections:Master
Department of Nutritional Sciences - Master theses

Files in This Item:

File Description SizeFormat
Cuda_Cristina_C_201006_MSc_Thesis.pdf506.68 kBAdobe PDF

This item is licensed under a Creative Commons License
Creative Commons

Items in T-Space are protected by copyright, with all rights reserved, unless otherwise indicated.