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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24567

Title: Characterization of the Mobility of FcγRIIa in Primary Human Macrophages
Authors: Farkash, Yoav
Advisor: Grinstein, Sergio
Department: Biochemistry
Keywords: Cell biology
Biochemistry
Issue Date: 26-Jul-2010
Abstract: Fcγ receptor-mediated phagocytosis is an active process requiring receptor clustering as a signal initiation event. The mechanisms controlling Fcγ receptor clustering are unknown, as are the parameters governing the receptor lateral mobility in the plasma membrane. This work investigated the lateral mobility of Fcγ receptor IIa in resting primary human macrophages using single-molecule tracking methodology. In the absence of ligands, the receptor was found to exist mostly as a monomeric species. Detailed receptor dynamics revealed the existence of two receptor populations: one that was mobile, the other confined. The actin cytoskeleton was shown to be important for receptor confinement but did not affect receptor diffusion. Such findings are important in understanding the mechanisms for receptor clustering and signal initiation in phagocytosis.
URI: http://hdl.handle.net/1807/24567
Appears in Collections:Master
Department of Biochemistry - Master theses

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