test Browse by Author Names Browse by Titles of Works Browse by Subjects of Works Browse by Issue Dates of Works
       

Advanced Search
Home   
 
Browse   
Communities
& Collections
  
Issue Date   
Author   
Title   
Subject   
 
Sign on to:   
Receive email
updates
  
My Account
authorized users
  
Edit Profile   
 
Help   
About T-Space   

T-Space at The University of Toronto Libraries >
School of Graduate Studies - Theses >
Master >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24586

Title: The Role of Hepoxilins in an Asthma-like Mouse Model
Authors: Kapeleris, Audrey
Advisor: Post, Martin
Department: Medical Science
Keywords: Hepoxilins
Asthma
Issue Date: 27-Jul-2010
Abstract: Asthma is a chronic respiratory illness where the airway occasionally constricts, becomes inflamed, and is lined with excessive amounts of mucus. There are many lipid mediators involved in this inflammatory response. Hepoxilins are biologically active hydroxyepoxy eicosatrienoic acid metabolites of arachidonic acid, formed through the 12-lipoxygenase pathway. Our goal in this study was to identify if hepoxilins had a direct effect on smooth muscle contractions, to identify the source of hepoxilins in asthmatic-like mouse model, and to determine if blocking this pathway reduced inflammation associated with ovalbumin sensitization. We found that hepoxilins had no direct effect on smooth muscle contraction. We identified the bronchiolar epithelium as a major source of hepoxilins in OVA-challenged mice. We demonstrated that baicalein inhibits total lung resistance in the OVA-treated mice, but also found that the drug in-vivo is not specific for 12-lipoxygenase.
URI: http://hdl.handle.net/1807/24586
Appears in Collections:Master
Institute of Medical Science - Master theses

Files in This Item:

File Description SizeFormat
Kapeleris_Audrey_P_201006_MSc_thesis.pdf20.79 MBAdobe PDF
View/Open

Items in T-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

uoft