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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24586

Title: The Role of Hepoxilins in an Asthma-like Mouse Model
Authors: Kapeleris, Audrey
Advisor: Post, Martin
Department: Medical Science
Keywords: Hepoxilins
Issue Date: 27-Jul-2010
Abstract: Asthma is a chronic respiratory illness where the airway occasionally constricts, becomes inflamed, and is lined with excessive amounts of mucus. There are many lipid mediators involved in this inflammatory response. Hepoxilins are biologically active hydroxyepoxy eicosatrienoic acid metabolites of arachidonic acid, formed through the 12-lipoxygenase pathway. Our goal in this study was to identify if hepoxilins had a direct effect on smooth muscle contractions, to identify the source of hepoxilins in asthmatic-like mouse model, and to determine if blocking this pathway reduced inflammation associated with ovalbumin sensitization. We found that hepoxilins had no direct effect on smooth muscle contraction. We identified the bronchiolar epithelium as a major source of hepoxilins in OVA-challenged mice. We demonstrated that baicalein inhibits total lung resistance in the OVA-treated mice, but also found that the drug in-vivo is not specific for 12-lipoxygenase.
URI: http://hdl.handle.net/1807/24586
Appears in Collections:Master
Institute of Medical Science - Master theses

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