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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24603

Title: A Survey of Functional Retroposed Genes: H. sapiens, M. musculus, D. melanogaster, and C. elegans
Authors: Mahmood, Sanaa
Advisor: Zhang, Zhaolei
Department: Molecular and Medical Genetics
Keywords: Retrogene
Chromosome X
Homo sapiens
Mus musculus
Drosophila melanogaster
Caenorhabditis elegans
Issue Date: 27-Jul-2010
Abstract: Retrogenes are functional genes that are created through retroposition, whereby mature mRNA is reverse-transcribed and re-integrated into the genome. In this study, the following objectives were accomplished: (i) intrachromosomal- and interchromosomal-retroposed genes were located in H. sapiens, (ii) interchromosomal-retroposed genes were located in M. musculus, D. melanogaster, and C. elegans. To date, this is the first assay for intrachromosomal-retroposed genes in H. sapiens and interchromosomal-retroposed genes in C. elegans. Biases discovered include excess interchromosomal generation of retrogenes by chromosome X in H. sapiens, M. musculus, and D. melanogaster. Selection pressure created by the inactivation of the X chromosome during male meiosis appears to be at least partially responsible for this phenomenon. In addition, excess interchromosomal recruitment of retrogenes by chromosome X was observed in H. sapiens. The driving force appears to be an interplay between selection for female-beneficial genes and selection for male-beneficial genes. No other chromosome biases were discovered.
URI: http://hdl.handle.net/1807/24603
Appears in Collections:Master
Department of Molecular Genetics - Master theses

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