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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24657

Title: The Role of the Coxsackie-adenovirus Receptor in the Pathogenesis of Heart Disease and Coxsackieviral Myocarditis
Authors: Yuen, Stella Lai Yee
Advisor: Opavsky, Mary Anne
Department: Medical Science
Keywords: immunology
virology
cardiomyopathy
coxsackie-adenovirus receptor
innate immunity
coxsackievirus B
MAP kinase signaling
Issue Date: 29-Jul-2010
Abstract: The coxsackie-adenovirus receptor (CAR) is a viral receptor for Group B coxsackieviruses (CVB). Physiologically, CAR is a cellular adhesion protein. I report that upregulation of cardiac CAR in the young adult mouse (CAR+/MtTA+ ) caused a cardiomyopathy that was characterized by inflammation and hypertrophy. In the hearts of CAR+/MtTA+ mice c-Jun N terminal kinase (JNK) was specifically activated. JNK activation is known to promote hypertrophy of cardiomyocytes, and disrupt proteins at the intercalated disc. CVB3-infected CAR+/MtTA+ mice did not exhibit increased cardiac viral load or myocarditis severity, but did demonstrate a greater cardiac interferon-γ (IFN-γ) response when compared to littermate controls. CAR-induced expression of this antiviral cytokine may have prevented the increase in myocarditis susceptibility. Further investigation into the activation of protein kinase signaling, and antiviral signaling will provide better understanding of how CAR participates in the pathogenesis of both viral and non-viral heart diseases.
URI: http://hdl.handle.net/1807/24657
Appears in Collections:Master
Institute of Medical Science - Master theses

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