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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24856

Title: Characterization of BMP Signalling Pathways Mediated by the BMP Type II Receptor, BMPRII, Regulating Neuronal Morphogenesis
Authors: Podkowa, Monika
Advisor: Attisano, Liliana
Department: Biochemistry
Keywords: cell biology
biochemistry
molecular biology
neuroscience
Issue Date: 1-Sep-2010
Abstract: Bone Morphogenetic Proteins (BMPs) regulate numerous biological processes including neuronal development. The growth and morphological differentiation of dendrites are critical events in the establishment of proper neuronal connectivity and neural function. One extrinsic factor, BMP7, has been shown to specifically affect dendritic morphogenesis. Here, I describe the elucidation of novel signalling mechanisms involving the BMP type II receptor, BMPRII, during BMP7-dependent dendrite formation. The carboxy-terminal tail of BMPRII binds regulators of the cytoskeleton, and acts as a scaffold to localize and coordinate cytoskeletal remodelling. BMP7-induced localized remodelling of the actin and microtubule cytoskeleton mediated by BMPRII-bound LIMK1 and JNK, contributes to BMP7-dependent dendrite formation. In addition, in efforts to understand how BMP-induced activation of LIMK1 and JNK is regulated, upstream regulators, Rho GTPase, Cdc42, a Rho GTPase effector, PAK1, and a guanine exchange factor (GEF), αPIX, were identified as novel interacting partners of the BMP type I receptor, ALK2. Thus, elucidation of the molecular mechanisms governing BMP7-dependent dendrite formation, defines the extracellular cue, BMP7, as a critical regulator of cytoskeletal dynamics in neurons.
URI: http://hdl.handle.net/1807/24856
Appears in Collections:Doctoral
Department of Biochemistry - Doctoral theses

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