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Till, James E. >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/24973

Title: Quantitation of Cellular Radiobiological Responses
Authors: Till, James E.
Whitmore, G. F.
Keywords: Radiobiology
Molecular Biology
Cell Proliferation
In Vivo
Mitotic Delay
Malignant Disease
Cell Renewal
Issue Date: Dec-1964
Publisher: Annual Reviews Inc
Citation: Annual Review of Nuclear Science 1964(Dec); 13: 347–374
Series/Report no.: Annual Review of Nuclear Science
Abstract: Problems of mammalian cell radiobiology can be approached from at least three points of view. One may search for the earliest detectable lesions at the molecular level and attempt to determine how these lesions affect the structure and function of individual cells. Examples of this approach have been applications of target theory and techniques of molecular biology to study radiation effects on cells or cell components ( 1-7) . Another approach is to study radiation effects at the cellular level, utilizing techniques which measure damage to single cells growing under controlled conditions. For example, one may study the loss of proliferative capacity, division delay, or changes in metabolic activity occurring in irradiated cells in tissue culture (8). A third approach is to study the effects of radiations on tissues, where cell interactions, differentiation stimuli, and growth-controlling processes may influence the response of cells to radiation (9). The ultimate aim of studies at each of these levels is to trace the development of damage within the irradiated mammalian cells from the initial energy absorption in some critical site up to the point of final expression of radiation effects in the complete mammalian system. The present state of our knowledge does not allow such a synthesis. In this review we will be primarily concerned with research at the second level, i.e., with experiments which determine the effect of radiation on cells of a single type, in most cases growing without complex interactions with cells of different types. We will further restrict ourselves to considerations of the effect of radiation on the proliferative processes of the cell. We will not discuss radiation effects on nonproliferating cells even though these are of obvious importance in vivo. Having presented a number of observations of such radiation effects, we shall present a concept which we feel may unify some of the observations and which may make possible predictions concerning the postirradiation behavior of cell populations. Finally we shall present some of the problems which arise in considering radiation effects on complex cell systems in vivo.
Description: Reprinted, with permission, from the Annual Review of Nuclear Science, Volume 14 (c)1964 by Annual Reviews www.annualreviews.org
URI: http://www.annualreviews.org/doi/abs/10.1146/annurev.ns.14.120164.002023
ISSN: 0066-4243
Appears in Collections:Till, James E.

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