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Till, James E. >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25091

Title: Radiation-Induced Mitotic Delay in L Cells
Authors: Whitmore, G. F.
Till, J. E.
Gulyas, S.
Keywords: radiation
mitotic delay
L Cells
irradiations
Issue Date: Jan-1967
Publisher: Radiation Research Society
Citation: WHITMORE GF, TILL JE, GULYAS S. Radiation-induced mitotic delay in L cells. Radiat Res. 1967;30(1):155-71.
Series/Report no.: Radiation Research
Volume 30 Issue 1
Abstract: A study has been made of the dependence of the dose-response curve for mitotic delay on the age of the cells at the time of irradiation. The results obtained for randomly dividing cultures with (H^3)TdR used to locate the position of the cells in the cell cycle at the time of irradiation indicated that mitotic delay increases from a value of 0.4 to 0.5 min/rad for cells irradiated in the G1 phase to a value of 2.3 to 2.4 min/rad for cells irradiated in G2. Cells irradiated in a portion of S gave an intermediate value. The number of cells that attempt the first post-irradiation mitosis decreases with dose more rapidly for cells irradiated in S or G2 than for cells irradiated in G1. Irradiation of cells that had been partially synchronized by exposure to FUdR yielded results that did not agree with those obtained with randomly dividing cultures.
Description: Reproduced with permission from the Radiation Research Society. Radiation Research Society allows published articles to be archived in institutional repositories. http://www.rrjournal.org/doi/abs/10.2307/3572041
URI: http://dx.doi.org/10.2307/3572041
http://www.rrjournal.org/
http://hdl.handle.net/1807/25091
ISSN: 0033-7587
Appears in Collections:Till, James E.

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