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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25405

Title: Serum BMP-2, 4, 7 and AHSG in Patients with Heterotopic Ossification Following Arthroplasty
Authors: Albilia, Jonathan
Advisor: Tenenbaum, Howard
Clokie, Cameron
Department: Dentistry
Keywords: heterotopic ossification
BMP
AHSG
arthritis
markers
arthroplasty
Joint
surgery
myossitis ossificans
Fetuin
Temporomandibular
Hip
Noggin
Alpha-2 HS glycoprotein
inflammatory
Issue Date: 14-Dec-2010
Abstract: Purpose: To determine whether reduced serum levels of AHSG and elevated levels of BMP-2, 4, 7 are associated with post-arthroplasty HO. Patients: Thirty arthroplasty patients were included, 15 with evidence of peri-articular HO and 15 without (NHO). Methods: Blood samples were collected from all patients ≥ 8 weeks after arthroplasty. Analytes were measured using ELISAs. Mann-Whitney U tests were performed to compare serum analyte concentrations between HO and NHO groups, and between arthroplasty patients and healthy humans. Results: There is no difference in serum concentrations of AHSG, BMP-2, 4, 7 between HO and NHO patients. Arthroplasty patients showed significantly higher BMP-2 and BMP-4 and lower AHSG serum levels compared to healthy humans (p < 0.01). Conclusion: Baseline BMP-2, 4, 7 and AHSG serum levels are not markers of acquired HO. However, elevated baseline levels of BMP- 2, 4 and reduced levels of AHSG appear to be markers of severe inflammatory arthritis.
URI: http://hdl.handle.net/1807/25405
Appears in Collections:Master
Faculty of Dentistry - Master theses

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