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T-Space at The University of Toronto Libraries >
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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25514

Title: Risk of Stroke in Older Women Treated for Early Invasive Breast Cancer, Tamoxifen vs. Aromatase Inhibitors: A Population based Retrospective Cohort Study
Authors: Wijeratne, Don Thiwanka Dilshan
Advisor: Rochon, Paula A.
Department: Health Policy, Management and Evaluation
Keywords: Stroke
Breast Cancer
Tamoxifen
Aromatase Inhibitors
Anastrozole
Letrozole
Population
Cohort
Retrospective
Administrative Databases
Issue Date: 30-Dec-2010
Abstract: Tamoxifen and aromatase inhibitors are treatment options for women with breast cancer and evidence on the risk of stroke is important in choosing between these two options. A systematic review of two randomized controlled trials and their nine related trial reports showed different methods for adverse event reporting and inconsistent estimates of stroke risk. In an observational cohort study of 5443 Ontario women, aged 66 years or older with early stage breast cancer, 86 ischemic stroke events (1.6%) occurred during follow-up of 5 years. There was no statistically significant difference in the risk of stroke between the hormone therapy groups [adjusted HR for tamoxifen compared to AI 1.330 (0.810, 2.179)]. Results were similar across cardiovascular disease risk groups and were robust to different follow up periods and analytic methods. This study suggests that there is no significant difference in stroke between these treatment options.
URI: http://hdl.handle.net/1807/25514
Appears in Collections:Master
The Institute of Health Policy, Management and Evaluation - Master theses

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