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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25561

Title: Metoprolol Impairs Mesenteric and Posterior Cerebral Artery Function in Mice
Authors: El Beheiry, Mostafa Hossam
Advisor: Hare, Gregory
Bolz, Steffen Sebastian
Department: Physiology
Keywords: mesenteric resistance artery
beta-blockers
metoprolol
beta-adrenergic receptor
posterior cerebral artery
isoproterenol
Issue Date: 31-Dec-2010
Abstract: Background/Rationale: In addition to their established cardioprotective role, β-adrenergic antagonists also increase the risk of stroke and mortality. We propose that a vascular mechanism could contribute to cerebral tissue ischemia in β-blocked patients. Methods: Cardiac output (CO), mean arterial pressure (MAP) and microvascular brain oxygen tension (PBrmvO2) were measured in anesthesized mice treated with metoprolol (3mg•kg-1, i.v.). Dose-response curves (DRCs) for adrenergic-agonists were generated in mesenteric resistance arteries (MRAs; isoproterenol, clenbuterol) and posterior cerebral arteries (PCAs; phenylephrine, isoproterenol) before and after metoprolol treatment. Results: Metoprolol reduced CO, maintained MAP and increased systemic vascular resistance (SVR) resulting in a decreased PBrmvO2 in mice. Metoprolol attenuated β-adrenergic mediated vasodilation in both MRAs and PCAs. Conclusions: Metoprolol reduced brain perfusion in mice. A decrease in CO contributed however, metoprolol also inhibited β-adrenergic vasodilation of mesenteric and cerebral arteries. This provides evidence in support of a vascular mechanism for cerebral ischemia in β-blocked patients.
URI: http://hdl.handle.net/1807/25561
Appears in Collections:Master
Department of Physiology - Master theses

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