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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25575

Title: Long Term Effects of Early Embryonic Ethanol Exposure, on Behavioural Performance and Learning in Zebrafish, Danio rerio
Authors: Fernandes, Yohaan
Advisor: Gerlai, Robert
Department: Psychology
Keywords: Fetal Alcohol Syndrome (FAS)
Fetal Alcohol Spectrum Disorders (FASDs)
Issue Date: 31-Dec-2010
Abstract: Background: Fetal alcohol syndrome (FAS) is a devastating disorder whose mechanisms may be best investigated using animal models. Here we present a novel zebrafish FAS model to investigate the effects of low to moderate alcohol exposure during early development on learning. Methods: At 24-hours postfertilization zebrafish embryos were exposed to low doses of ethanol (external concentrations = 0.00, 0.25, 0.50, 0.75 and 1.00% vol/vol) for a very short duration (2 hours). Upon adulthood associative learning in the zebrafish was tested in a plus maze. Results: This exposure led to no gross anatomical abnormalities or increased morbidity or mortality. Overall activity was not significantly affected by embryonic ethanol exposure. A trend towards a dose-dependent decrease in learning and memory performance was observed. Conclusions: We suggest that zebrafish will be an appropriate model with which one can analyze the behavioural effects of embryonic alcohol exposure and the mechanisms of the ensuing abnormalities.
URI: http://hdl.handle.net/1807/25575
Appears in Collections:Master
Department of Psychology - Master theses

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