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|Title: ||Long Term Effects of Early Embryonic Ethanol Exposure, on Behavioural Performance and Learning in Zebrafish, Danio rerio|
|Authors: ||Fernandes, Yohaan|
|Advisor: ||Gerlai, Robert|
|Keywords: ||Fetal Alcohol Syndrome (FAS)|
Fetal Alcohol Spectrum Disorders (FASDs)
|Issue Date: ||31-Dec-2010|
|Abstract: ||Background: Fetal alcohol syndrome (FAS) is a devastating disorder whose mechanisms may be best investigated using animal models. Here we present a novel zebrafish FAS model to investigate the effects of low to moderate alcohol exposure during early development on learning.
Methods: At 24-hours postfertilization zebrafish embryos were exposed to low doses of ethanol (external concentrations = 0.00, 0.25, 0.50, 0.75 and 1.00% vol/vol) for a very short duration (2 hours). Upon adulthood associative learning in the zebrafish was tested in a plus maze.
Results: This exposure led to no gross anatomical abnormalities or increased morbidity or mortality. Overall activity was not significantly affected by embryonic ethanol exposure. A trend towards a dose-dependent decrease in learning and memory performance was observed. Conclusions: We suggest that zebrafish will be an appropriate model with which one can analyze the behavioural effects of embryonic alcohol exposure and the mechanisms of the ensuing abnormalities.|
|Appears in Collections:||Master|
Department of Psychology - Master theses
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