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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25583

Title: Microsphere Kinetics in Chronic Total Occlusions
Authors: Fraser, Ashley
Advisor: Strauss, Bradley
Department: Biomedical Engineering
Keywords: Chronic Total Occlusion
Polymer microsphere
Controlled Release
Issue Date: 31-Dec-2010
Abstract: Chronic total occlusions are a common problem in patients with coronary artery disease. The primary barrier to successful percutaneous coronary intervention is inability to cross the lesion with a guidewire. We seek to characterize polymer microspheres as a controlled delivery mechanism for collagenase and VEGF, novel intralesional therapies being investigated to alter CTO structural properties. Release profiles for protein-loaded PLGA [poly(lactic-co-glycolic acid)] microspheres showed sustained BSA and VEGF release over eight and 48 hours respectively. Polymer degradation products had no impact on endothelial cell growth and protein bioactivity was maintained post-release. In vivo localization of microsphere-released collagenase was not possible due to low concentrations remaining at the site. Histology confirmed microspheres remained in the collagen-dense, proximal 15 mm of the lesion, likely altering the structural integrity of the plaque.
URI: http://hdl.handle.net/1807/25583
Appears in Collections:Master
Institute of Biomaterials and Biomedical Engineering - Master theses

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