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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25719

Title: Paraesthesia Following Dental Local Anaesthetic Administration in the United States
Authors: Garisto, Gabriella Amneris
Advisor: Haas, Daniel
Department: Dentistry
Keywords: Paraesthesia
Articaine
Prilocaine
Inferior alveolar nerve
Lingual nerve
Local Anaesthetics
Dentistry
Issue Date: 6-Jan-2011
Abstract: Background: Several studies have suggested that the likelihood of paraesthesia may depend on the local anaesthetic (LA) used. The purpose of this study was to analyze reports of paraesthesia among dental LAs used in the U.S. Methods: Reports of paraesthesia involving LAs between November 1997 through August 2008 were obtained from the U.S. Food and Drug Administration Adverse Event Reporting System. Chi-Square analysis compared expected frequencies, based on U.S. LA sales data, to observed reports of oral paraesthesia. Results: During the study period 248 cases of paraesthesia following dental procedures were reported. Most (94.5%) cases involved mandibular nerve block. The lingual nerve was affected in 89.0% of cases. Reports involving 4%-prilocaine and 4%-articaine were 7.3-times and 3.6-times, respectively, greater than expected (χ2, p<0.0001) based on LA usage by U.S. dentists. Conclusions: Consistent with previous reports, these data suggest that paraesthesia is more common following use of 4% LA formulations.
URI: http://hdl.handle.net/1807/25719
Appears in Collections:Master
Faculty of Dentistry - Master theses

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