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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25722

Title: Correlating Neuropsychiatric Symptoms with Regional Beta-Amyloid Load in the Alzheimer’s Disease Brain Using [11C]SB-13 Positron Emission Tomography
Authors: Kaye, Edward David
Advisor: Verhoeff, Nicolaas Paul L. G.
van Reekum, Robert
Department: Medical Science
Keywords: Alzheimer's Disease
beta-amyloid
behaviour
neuropsychiatric symptoms
neuroimaging
positron emission tomography
PET
SB-13
Issue Date: 6-Jan-2011
Abstract: Correlations between neuropsychiatric symptoms and beta-amyloid (Aβ) burden in specific brain regions in living Alzheimer’s disease (AD) patients remain to be elucidated. Ten mild AD patients underwent MR and [11C]SB-13 PET imaging. Neuropsychiatric symptoms were quantified with the Neuropsychiatric Inventory (NPI). NPI-depression/dysphoria, -apathy, -agitation/aggression, -anxiety, and -appetite/eating disorders scores were hypothesized to correlate with Aβ burden in particular brain regions. Pearson’s correlation coefficient revealed that depression/dysphoria scores positively correlated (p<0.05) with standardized uptake values (SUVs) from left medial temporal lobe (r=0.67), and agitation/aggression correlated with SUVs from bilateral anterior cingulate (right, r=0.71; left, r=0.78), temporal (right, r=0.71; left, r=0.75), parietal (right, r=0.77; left, r=0.81), and dorsolateral prefrontal cortex (right, r=0.74; left, r=0.73). However, NPI scores did not significantly correlate with better estimates of Aβ burden that use the cerebellum as reference region. Overall, our results confirm the lack of association between Aβ burden and neuropsychiatric symptoms reported in autopsy studies.
URI: http://hdl.handle.net/1807/25722
Appears in Collections:Master
Institute of Medical Science - Master theses

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