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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25738

Title: Differential Effects of PPAR-γ Activation vs. Chemical or Genetic Reduction of DPP-4 Activity on Murine Bone Quality
Authors: Kyle, Kimberly Anne
Advisor: Grynpas, Marc D.
Department: Laboratory Medicine and Pathobiology
Keywords: Bone Quality
Osteoporosis
Diabetes
Thiazolidinediones
DPP-4 Inhibitors
Issue Date: 7-Jan-2011
Abstract: This study characterized the effects of two anti-diabetic drugs, a thiazolidinedione (TZD) and a Dipeptidyl Peptidase-4 (DPP-4) inhibitor on bone quality in a glucose intolerant mouse model. Bone quality in a DPP-4 -/- mouse model was also examined. Bone quality was evaluated through densitometry, mechanical testing and techniques to assess remodeling, structural and mineral properties. TZD treatment negatively affected trabecular mechanical properties in male, female and ovariectomized female (OVX) mice. Male mice exhibited the greatest effect due to TZD treatment with reduced vertebral vBMD, trabecular structure and bone formation. DPP-4 inhibitor treatment improved vertebral vBMD and trabecular architecture in female mice but improvements were lost in females following OVX. Male, female and OVX mice experienced increased trabecular mineralization due to DPP-4 inhibitor treatment. Genetic inactivation of DPP-4 did not produce a major bone phenotype in male and female mice but lead to reduced femoral geometry and mechanics in OVX mice.
URI: http://hdl.handle.net/1807/25738
Appears in Collections:Master
Department of Laboratory Medicine and Pathobiology - Master theses

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