test Browse by Author Names Browse by Titles of Works Browse by Subjects of Works Browse by Issue Dates of Works

Advanced Search
& Collections
Issue Date   
Sign on to:   
Receive email
My Account
authorized users
Edit Profile   
About T-Space   

T-Space at The University of Toronto Libraries >
School of Graduate Studies - Theses >
Master >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25749

Title: Mechanical Evaluation of a Thiol-modified Hyaluronan Elastin-like Polypeptide Nucleus Pulposus Replacement Material in Porcine Intervertebral Discs
Authors: Leckie, Ashley
Advisor: Whyne, Cari
Yee, Albert
Department: Biomedical Engineering
Keywords: Nucleus Pulposus Replacement
Issue Date: 7-Jan-2011
Abstract: Mechanical low back pain is a disabling condition often associated with degenerative disc disease (DDD). Treatment for DDD includes non-operative pain management, total disc arthroplasty and nucleus pulposus (NP) replacement. A thiol-modified hyaluronan elastin-like polypeptide (TMHA/EP) composite has been under consideration as a NP replacement and has shown promise in vitro. This thesis aims to determine the effects of TMHA/EP composite augmentation on spinal motion segment mechanics in healthy and induced early stage DDD porcine intervertebral discs (IVD). Healthy IVD augmentation on average increased axial compressive stiffness, while bending and rotational stability decreased. Early stage DDD porcine IVD had compromised mechanical integrity in comparison to healthy controls. TMHA/EP augmentation of the mechanically compromised IVDs through two injection techniques worked to restore spinal stability, exhibiting mechanical properties similar to healthy IVDs. This work demonstrates the potential of the injectable TMHA/EP composite in providing initial structural stabilization in early stages of DDD.
URI: http://hdl.handle.net/1807/25749
Appears in Collections:Master
Institute of Biomaterials and Biomedical Engineering - Master theses

Files in This Item:

File Description SizeFormat
Leckie_Ashley_E_201011_MASc_thesis.pdf864.88 kBAdobe PDF

Items in T-Space are protected by copyright, with all rights reserved, unless otherwise indicated.