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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25758

Title: A Platform to Monitor Tumor Cellular and Vascular Response to Radiation Therapy by Optical Coherence Tomography and Fluorescence Microscopy in vivo
Authors: Leung, Michael Ka Kit
Advisor: Vitkin, Alex
Department: Medical Biophysics
Keywords: Optical Coherence Tomography
Fluorescence Microscopy
Radiation Therapy
Vasculature
Laser
Issue Date: 10-Jan-2011
Abstract: Radiotherapy plays a significant role in cancer treatment, and is thought to be curative by mainly killing tumor cells through damage to their genetic material. However, recent findings indicate that the tumor’s vascular blood supply is also a major determinant of radiation response. The goals of this thesis are to: (1) develop an experimental platform for small animals to deliver ionizing radiation and perform high-resolution optical imaging to treatment targets, and (2) use this toolkit to longitudinally monitor the response of tumors and the associated vasculature. The thesis has achieved: (1) customization of a novel micro-irradiator for mice, (2) technical development of an improved optical coherence tomography imaging system, (3) comprehensive experimental protocol and imaging optimization for optical microscopy in a specialized animal model, and (4) completion of a feasibility study to demonstrate the capabilities of the experimental platform in monitoring the response of tumor and vasculature to radiotherapy.
URI: http://hdl.handle.net/1807/25758
Appears in Collections:Master
Department of Medical Biophysics - Master theses

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