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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25765

Title: The Dosimetric Consequences of Intensity Modulated Radiotherapy for Cervix Cancer - the Impact of Organ Motion, Deformation and Tumour Regression
Authors: Lim, Karen
Advisor: Milosevic, Michael
Fyles, Anthony
Department: Medical Science
Keywords: cervix cancer
intensity modulated radiotherapy
consensus guidelines
dose accumulation
organ motion
Issue Date: 10-Jan-2011
Abstract: Cervix cancer affects women of all ages and causes significant morbidity and mortality. Locally advanced disease is curable with radiotherapy (RT) in about 50% of patients, although often at the expense of serious side effects. In order to improve the therapeutic ratio of tumour control versus normal tissue toxicity, conformal intensity-modulated radiotherapy (IMRT) is being investigated. However, inter- and intra-fractional motion of cervix cancer can contribute to both geographical miss of the target and overdosing of surrounding normal tissues, particularly in the setting of conformal IMRT with steep dose gradients. Defining the target volume accurately and understanding the dose consequence of these complex intra-pelvic organ dynamics during external beam radiotherapy forms the essential foundations for future treatment optimization and adaptation. This in turn will lead to improvements in tumour control and disease-free survival while minimising treatment toxicity.
URI: http://hdl.handle.net/1807/25765
Appears in Collections:Master
Institute of Medical Science - Master theses

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