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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25771

Title: Concurrent Self-administration of Alcohol and Nicotine in an Operant Paradigm
Authors: Lo, Ching-Han
Advisor: Le, Anh Dzung
Department: Pharmacology
Keywords: Alcohol
Nicotine
Self-Administration
Drug abuse
Drinking
Smoking
Rats
Issue Date: 10-Jan-2011
Abstract: Rationale and objectives: Alcohol and nicotine are the most commonly abused drugs and they are often taken together. To help address some of clinical issues regarding nicotine and alcohol co-dependence, a procedure in which rats self-administer nicotine intravenously and alcohol orally during the same operant session has been developed. Methods: Male Wistar rats were trained to self-administer alcohol (12%, w/v; 0.19 ml/delivery) or implanted with jugular catheters and trained to self-administer nicotine (30 μg/kg IV/infusion) by pressing a lever or were trained to self-administer both drugs, some with alcohol first, and others with nicotine first. Results: Animals readily coadministered alcohol and nicotine concurrently. Access to alcohol reduced nicotine selfadministration significantly. Conclusions: These results show that rats will self-administer relevant amounts of intravenous nicotine and oral alcohol concurrently. They also provide further support for the important relationship between nicotine and alcohol.
URI: http://hdl.handle.net/1807/25771
Appears in Collections:Master
Department of Pharmacology and Toxicology - Master theses

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