T-Space at The University of Toronto Libraries >
School of Graduate Studies - Theses >
Please use this identifier to cite or link to this item:
|Title: ||High Frequency Ultrasound Backscatter Analysis for the Detection of Early Tumour Response to Radiotherapy and a Novel Anti-vascular Treatment|
|Authors: ||Lee, Justin|
|Advisor: ||Czarnota, Gregory J.|
|Department: ||Medical Biophysics|
|Issue Date: ||10-Jan-2011|
|Abstract: ||There is a need for cancer imaging to provide “real-time” information about the cellular responses of tumours in contrast to standard evaluations of tumour size. Quantitative ultrasound techniques have recently been demonstrated to be a potential method of assessing tumour response at the cellular level through the analysis of radiofrequency backscatter data.
In this thesis, prostate cancer xenografts were evaluated in vivo using high-frequency ultrasound analysis techniques to assess tumour response. The anti-cancer treatments consisted of radiotherapy and also a novel anti-vascular therapy utilizing encapsulated microbubble agents in the presence of ultrasound. Quantitative ultrasound results demonstrated a statistically significant change in backscatter parameters in tumours treated with high doses of radiotherapy or a high concentration of microbubbles during treatments. Histopathological assessment demonstrated that tumour cell death due to apoptosis and necrosis correlated with increases in ultrasound parameters.|
|Appears in Collections:||Master|
Department of Medical Biophysics - Master theses
Items in T-Space are protected by copyright, with all rights reserved, unless otherwise indicated.