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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25802

Title: Age Related Tissue Fibrosis During Fracture Repair Is Mediated by Wnt/β-catenin Signaling
Authors: Silkstone, David
Advisor: Benjamin, Alman
Department: Medical Science
Keywords: Fracture Repair
Elderly
Osteoblasts
Tissue Fibrosis
Wnt/β-catenin Signaling
Multipotent Mesenchymal Stem Cells
Issue Date: 11-Jan-2011
Abstract: The regenerative potential of tissue injury declines with age. Recently, a significant role for Wnt/β-catenin signaling has been shown in tissue specific stem cell aging, leading to increased tissue fibrosis. Wnt/β-catenin signaling regulates the differentiation of multipotent mesenchymal stem cells into osteoblasts during fracture repair. We investigated the potential role of dysregulated Wnt/β-catenin signaling in delayed fracture union and tissue fibrosis in the elderly. Old mice displayed increased total β-catenin protein levels at 4 and 7 days post-fracture and tissue fibrosis at 14 and 21 days post-fracture compared to young mice. Furthermore, treatment with a pharmalogical agent decreased total β-catenin protein levels in the fracture callus at 4 days post-fracture and prevented tissue fibrosis at 21 days post-fracture. Our data suggests that dysregulated Wnt/β-catenin signaling in the elderly contributes to delayed fracture repair and tissue fibrosis and offers a potential therapeutic strategy to improve fracture outcome in the elderly.
URI: http://hdl.handle.net/1807/25802
Appears in Collections:Master

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