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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/25865

Title: Detection of Prenatal Opiate Exposures in Alternative Matrices
Authors: Moller, Monique
Advisor: Koren, Gideon
Department: Pharmacology
Keywords: Drug
Opiate
Hair
Prenatal
Issue Date: 12-Jan-2011
Abstract: Identification of maternal opioid abuse in pregnancy is often difficult to ascertain in the absence of reliable self report. For this reason, physicians and child protection workers often turn to maternal and neonatal hair analysis for the detection of in utero opioid exposures. Since neonatal opiate hair analysis continues to prove difficult due to the scarcity of the hair sample and low drug concentrations, I developed a sensitive method utilizing headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS) for the detection of three principal opiates (morphine, codeine, and 6-monoacetylmorphine) in human hair. Moreover, I characterized an at-risk neonatal population for in utero opiate exposures as well as for other drugs of abuse and alcohol. Equipped with a sensitive and specific method for the detection of opiate exposures and understanding the addiction profiles of pregnant women may lead to better clinical and social management and may benefit an at-risk population.
URI: http://hdl.handle.net/1807/25865
Appears in Collections:Master

Files in This Item:

File Description SizeFormat
PDF_published_article.pdfPublication to be included in appendix346.63 kBAdobe PDF
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published paper.pdfSecond publication to be included in appendix156.75 kBAdobe PDF
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Moller_Monique_J_201011_MSc_thesis.pdfM.Sc. thesis submission for Monique Moller1.07 MBAdobe PDF
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